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To analyze risk factors for death in individuals with severe acute respiratory syndrome due to COVID-19. This was a retrospective cohort study, comprised of adult individuals with COVID-19, from March to September 2020, notified by the Epidemiological Surveillance System in the state of Acre, Brazil. Cox regression was used. Among 57,700 individuals analyzed, the incidence was 2,765.4/100,000 inhabitants, and mortality was, 61.8/100,000 inhabitants. The risk factors for death were being male (HR=1.48 -95% CI 1.25;1.76), age ≥60 years (HR=
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