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985) and cut-off score of 18 was suggested which showed a good sensitivity (0.984) and specificity (0.826) as well as excellent values for the positive and negative prediction values within all groups using the CIS as golden standard. Factor analysis showed a one factor solution (Eigenvalue 3.095) with factor loadings of all items on the factor being greater than 0.87. The SFQ is an easy to use, reliable and valid instrument to screen for severe fatigue in clinical routine and research. The SFQ is an easy to use, reliable and valid instr