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784), followed by ANN (0.73, SVM (0.73, GBM (0.676), and finally RF (0.649). LR also had good performance in other measures, such as F -score (0.79, specificity (0.737), sensitivity (0.833), and Matthews correlation coefficient (0.572). Cross-sectional design and limited sample size is limitations. This study demonstrated that HRV can be used to differentiate panic disorder from other anxiety disorders. Future studies with larger sample sizes and longitudinal design are required to replicate the diagnostic utility of HRV in a mac