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First Line Treatment For ADHD in Adults Some people with ADHD are able to use medications to manage their symptoms. Stimulants, such as amphetamine and methylphenidate are effective in boosting activity in brain regions that control the behavior and attention. Other medications, like the non-stimulant drug atomoxetine and some antidepressants work differently, but they are effective. Regular visits to the GP are recommended for people who are taking medication.