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Next generation sequencing data had been recovered and analyzed for recurrent hereditary abnormalities in these cases. Analytical analysis ended up being done utilizing IBM SPSS25 software. RB1 mutatichemical markers, and small, usually invisible primary tumors, the localization of the main tumor in situations of metastatic NECs is a challenge. In this study, RB1 and CDKN gene family mutations are recognized as feasible markers for differentiating pulmonary and non-pulmonary beginning in metatsta

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