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Appearance of an essential gene within the D. citri endosymbiont, Wolbachia (wDi), substantially reduced by 30% after incubation with a wDi-specific FANA ASO. Viability of isolated wDi cells additionally decreased in reaction to your FANA ASO treatment. Delivery of a CLas-specific FANA ASO to contaminated person D. citri in feeding assays triggered considerable silencing of a CLas crucial gene. CLas relative thickness and transmission were dramatically lower among D. citri