https://www.selleckchem.com/pr....oducts/Temsirolimus.
Hydrogen/deuterium exchange (HDX) is used in protein biophysics to probe folding dynamics, intermolecular interactions, epitope and other mapping [1, 2]. A typical procedure often involves HDX in buffered D2O solution followed by pepsin digestion, and liquid chromatography/electrospray ionization Mass Spectrometry (LC-ESI-MS) analysis. In this work, HDX of protein ions was conducted in the ESI source. Both native electrospray (ESI) droplets of ubiquitin and denatured myoglobin were exposed to D2O vapor in the source region of a Bru
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