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Acute hospitalization may lead to a decrease in muscle measures, but limited studies are reporting on the changes after discharge. The aim of this study was to determine longitudinal changes in muscle mass, muscle strength, and physical performance in acutely hospitalized older adults from admission up to 3months post-discharge. A prospective observational cohort study was conducted. This study included 401 participants aged ≥70years who were acutely hospitalized in 6 hospitals. All variables were assessed at hospital admission, discharge