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To compare hazard ratios obtained by using time on study (conventional) versus biological age as the time-scale in survival analyses for a known age-dependent association between an exposure and outcome. We conducted a retrospective cohort study of 9 million people in Ontario, Canada who were followed from 2003 to 2018 to identify incident ischemic stroke using linked administrative health data. Using cause-specific hazards models, we calculated hazard ratios (HR) of ischemic stroke in women compared to men using the two different time sca
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