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Favorable and optimal performance of machine learning on HD severity prediction was achieved using feature selection, giving a correlation coefficient (r) of .7516 and a coefficient of determination (R2 ) of .5649 (P less then .001). CONCLUSION The brain morphological changes were associated with HD. Excellent prediction of the severity of HD was achieved using machine learning based on neuroimaging. © 2020 The Authors. CNS Neuroscience Therapeutics Published by John Wiley Sons Ltd.OBJECTIVE To assess whether quantitative ch
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