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To assess changes in optic nerve sheath diameter (ONSD) at high altitude and in acute mountain sickness (AMS). Cochrane Library, EMBASE, Google Scholar and PubMed were searched for articles published from their inception to 31st of July 2020. Outcome measures were mean changes of ONSD at high altitude and difference in ONSD change between subjects with and without AMS. Meta-regressions were conducted to investigate the relation of ONSD change to altitude and time spent at that altitude. Eight studies with 248 participants comparing ONS
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