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The pooled proportions of people persistent at six months, one year, and two years were 80.1% (95% CI 75.8-84., 61.8% (95% CI 57.8-65.7), and 45.9% (95% CI 35.5-56.5), respectively. When persistence was defined as absence of ≥90-days gap, the equivalent pooled proportions persistent were 81.5% (95% CI 73.1-88.6), 58.9% (95% CI 53.1-64.6), and 34.7% (95% CI 33.6-35.8). Data from the United States suggested higher adherence and persistence with canagliflozin compared to dapagliflozin. Conclusion Real world adherence and persistence to SGLT2 inhibitors is po