https://www.selleckchem.com/pr....oducts/LY2603618-IC-
OBJECTIVES Mutations in SQSTM1 are strongly associated with Paget's disease of bone (PD but little is known about the clinical characteristics of those with early disease. METHODS Radionuclide bone scans, biochemical markers of bone turnover and clinical characteristics were analysed in SQSTM1 mutation carriers who took part in the Zoledronic acid in the Prevention of Paget's disease (ZiPP) study. RESULTS We studied 222 individuals of whom 54.9% were female with average (± sem) age of 50.1± 0.6 years. Twelve SQSTM1 mutations w
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