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For the quantitation study, method development focused on chromatographic optimizations to achieve maximum sensitivity. The developed dereplication and quantitation strategy can be extended to develop comprehensive metabolic profiles of other plant genera and species and thus can prove useful in the field of drug discovery from plants. © 2020 THE AUTHORS. Published by Elsevier BV on behalf of Cairo University.Background Clinical studies suggest obesity paradoxically increases survival during bacterial infection and sepsis but decreases it