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The tumor grade (HR = 571.72 [11.03-2.96] = 0.002), PD-L1 expression (HR = 2.33 [0.92-1.92] = 0.012), and expression (HR = 0.08 [0.17-0.42] = 0.003) were associated with relapse-free survival. tumor grade in association with PD-L1 and expression can be considered as a complex predictor for primary luminal NMIBC progression. tumor grade in association with PD-L1 and FGFR3 expression can be considered as a complex predictor for primary luminal NMIBC progression.The bone protective effects of carotenoids have been demonstrated in several stud