https://www.selleckchem.com/pr....oducts/tofa-rmi14514
After RA treatment, chromatin immunoprecipitation assays using an antibody against NCOR1, revealed that NCOR1 binding to RARβ promoters was significantly lower in Sirt1-/- mESCs than in Sirt1+/+ mESCs, and luciferase reporter assays showed SIRT1 knockdown decreased RA-induced RARα activity. Taken together, these observations show SIRT1 is required during the early phase of mESC adipogenesis and that SIRT1 deficiency inhibits adipogenesis by increasing NCOR1 acetylation and down-regulating the expressions of RARα and RARβ. Myeloid-
Like
Comment
Share
