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The network that is exclusively trained on simulated datasets can predict cortical parameters from the experimental UGW data. The proposed method is confirmed by using FDTD simulation signals and experimental data obtained from four bone-mimicking plates and from ten exvivo bovine cortical bones. The estimated root-mean-squared error (RMSE) in the simulated test data for the longitudinal bulk velocity (VL), transverse bulk velocity (VT), and cortical thickness (Th) is 97 m/s, 53 m/s and 0.089 mm, respectively. The predicted RMSE in the