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Following irradiation, we show that Lgr5+ISC repair DNA damage more efficiently than their particular progenitors and therefore this security is Atg7 dependent. Appropriately, we found that the stimulation of autophagy on fasting protects Lgr5+ISC against DNA damage and mobile demise mediated by oxaliplatin and doxorubicin treatments. Eventually, p53 removal prevents the death of Atg7-deficient Lgr5+ISC but promotes hereditary instability and tumefaction development. Completely, our results supply ideas into t
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