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Health Issues That Affect German Shepherd Life Expectancy German Shepherds are in their prime between the ages of 2 and 6 years old. They are at their best in terms of physical fitness and mental sharpness. They are more at risk of developing diseases of the musculoskeletal system, cancer, and other health issues that could affect their lives. Working line German Shepherds usually have more active lives than their show line counterparts. They require a nutritious diet to support their activity levels and workout demands. Cushing'