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Adult ADHD and Comorbid Disorders Many people with ADHD also have comorbid disorders, such as major depression (Kessler and colleagues, 2006). Many patients do not respond to medications for depression and may be able to benefit from psychotherapy. Medications that most effectively improve core symptoms of ADHD are those that boost and balance levels of specific brain chemicals called neurotransmitters. Drugs that stimulate the brain such as methylphenidate or amphetamine are frequently prescribed. Medi

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