https://www.selleckchem.com/pr....oducts/Metformin-hyd
DNA double-strand break (DS is a serious type of DNA damage and is known to trigger multiple responses within cells. In the responses, novel relationships among DSB, DSB repair and transcription machineries are created. First, transcription is repressed if DSB occurs near or at the transcription site, termed DSB-induced transcriptional repression, which contributes to DSB repair with the aid of DNA damage-signaling pathways, ATM- or DNA-PKcs-signaling pathway. DSB-induced transcriptional repression is also
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