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Taken together, we prove that baicalin pretreatment stops LPS-induced infection in RAW264.7 cells in CD14-dependent way. This research supports the healing usage of baicalin in avoiding the development of LPS-induced inflammatory diseases.Sphingosine-1-phosphate (S1P) as well as its receptors have already been implicated in features of Langerhans cells and atopic dermatitis. In this research, we investigated the roles of S1P receptor type 2 (S1P2) in a mouse model of atopic dermatitis, whi