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Complete loss of E-cadherin expression was observed in approximately a quarter of both SRCHCs as well as in all ILC cases. PIK3CA mutations were detected in all three sequenced cases (two axillary SRCHCs and one eyelid SRCHC). The histopathological, immunohistochemical, and genetic findings suggest that both SRCHCs are phenotypic variants of AC, although there are differences in sex, macroscopic findings, and the frequency of lymph node metastasis among the three. In contrast, ILC differs from the three tumour types. The histopathologi
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