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024, pain score P = 0.041) and 50MBq/kg group (pain score P = 0.021) at week 12. No patients withdrew trial because of AEs in three groups. Re-HEDP at dose of 40 and 50MBq/kg was generally effective to alleviate pain and improve QOL in lung cancer patients with painful bone metastases. Re-HEDP was safe and well-tolerated. 188Re-HEDP at dose of 40 and 50 MBq/kg was generally effective to alleviate pain and improve QOL in lung cancer patients with painful bone metastases. 188Re-HEDP was safe and well-tolerated.The mechanisms underlying pos