https://www.selleckchem.com/pr....oducts/SB-525334.htm
In experiments with multiple quantitative measurements per subject, for example measurements on multiple lesions per patient, the additional measurements on the same patient provide limited additional information. Treating these measurements as independent observations will produce biased estimators for standard deviations and confidence intervals, and increases the risk of false positives in statistical tests. The problem can be remedied in a simple way by first taking the average of all observations of each specific patient, and the
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