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BACKGROUND AIMS It is not clear whether screening colonoscopies provide any benefit to persons with negative results from a fecal immunochemical test (FIT). We investigated detection of CRC by colonoscopy in asymptomatic, average-risk, FIT-negative subjects METHODS We conducted a retrospective, population-based cohort study of 96,804 subjects with an initial negative result from a FIT at ages 50-75 y, from 2008 through 2014, who then underwent colonoscopy, using the Kaiser Permanente California databases. We identified participant