https://www.selleckchem.com/pr....oducts/gkt137831.htm
Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock. Increased inflammation, Toll-like receptor 4 activation, and decreased response of the alpha-1 adrenergic receptors which control vascular tone have been reported in trauma/hemorrhagic shock. In trauma/hemorrhagic shock, Toll-like receptor 4 activation contributes to vascular failure via decreased bioavail
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