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8% [95% confidence interval (CI) 0.4-1.3] and 0.6% (95% CI 0.0-1.6), respectively, at W48. VSS rate at W48 was 85.0% (95% CI 82.3-87.5) for DTG+3TC regimen and 92.4% (95% CI 85.0-97.7) in the DTG+RPV regimen. The DTG+3TC and DTG+RPV regimens led to discontinuations in 13.6% (95% CI 11.1-16.2) and 7.2% (95% CI 2.1-14.4) of patients, respectively, at W48. Similar results were observed at W96. Treatment with DTG+3TC or DTG+RPV in clinical practice provides a low rate of VF and a high rate of VS when initiated in virologically suppressed PLHIV