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The purpose of this paper is to review the pathophysiologic mechanisms, differential diagnosis, evaluation and treatment of the various manifestations of ocular allergy, with an especial focus on IgE-mediated disease. A PubMed search was performed to include articles with the search terms ocular allergy and allergic conjunctivitis. Recent and relevant human studies in the English language pertaining to our topic of study were selected. Animal studies pertaining to pathophysiology of ocular allergy were also reviewed. We