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RESULTS The CMC Controller Plus orthosis improved the patients' functional status and reduced their pain. The effect size for the change in function was large (1.29) compared to the effect size for the reduction in pain which approached moderate at 0.49. DISCUSSION The CMC Controller Plus orthosis improved the patient's functional status by 52% and reduced their pain by 29%. CONCLUSION The results were both statistically and clinically significant. Obsessive-compulsive disorder (OCD) is increasingly considered to be a neurodevelopmental