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The physical ground for the random distribution algorithm for alloys in discrete interaction models is explained in detail and verified by a statistical analysis. For nanoparticles below 4 nm a sampling strategy is recommended.Stimulated emission depletion (STED) nanoscopy is a promising fluorescence microscopy to detect unresolvable structures at the nanoscale level and then achieve a superior imaging resolution in materials science and biological research. However, in addition to the optimization of the microscope, luminescent material