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We aimed to clarify the prevalence, indications, analgesic comedications and complications of prescription opioid use in patients presenting to a large emergency department (ED). Retrospective chart review. Large, interdisciplinary ED of a public hospital. All patients aged ≥18 years presenting between 1 January 2017, and 31 December 2018, with documentation on medication were included. None. Prevalence rates for prescription opioid use and its indication. Prevalence of analgesic comedications in prescription opioid users. Hospitalisa