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Although some structures of CMP kinase have been determined, only minimal structural information has been readily available in the conformational modifications over the response pathway. We determined five crystal structures of CMP kinase of Thermus thermophilus HB8 in ligand-free kind and the CMP "open", CMP "closed", ADP-CDP-Gd3+-, and CDP-bound types at resolutions of 1.7, 2.2, 1.5, 1.6, and 1.7 Å, correspondingly. The ligand-free t
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