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Nitrous oxide (N O) abuse has become an increasingly severe problem in China. The aim of the study was to summarize the features of N O-induced neurology and enhance the awareness of this disease among physicians. We retrospectively reviewed the clinical, imaging, electrophysiological characteristics and the prognosis of patients with N O neurotoxicity in our hospital from January 2016 to August 2019. Twenty-one patients (average age 22.6±4.6 years) were collected. Eighty-six percent (18/21) patients presented with acute or subacute neurological disorders a