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Prediction errors for peak inspiratory volume for an increase of 16 cmH2O were 80 [30 - 140] mL (15.9 [8.4 - 31.0]%), with RMS fitting errors of 0.05 [0.03 - 0.12] L. These results show very good prediction accuracy able to guide personalised MV care. One of the main steps in the planning of radiotherapy (RT) is the segmentation of organs at risk (OARs) in Computed Tomography (CT). The esophagus is one of the most difficult OARs to segment. The boundaries between the esophagus and other surrounding tissues are not well-defined, and it is