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This was an extremely rare case showing chemoresistance due to epithelial-mesenchymal transition. Mucinous urethral adenocarcinoma is difficult to diagnose in coexistence with prostate adenocarcinoma. This was an extremely rare case showing chemoresistance due to epithelial-mesenchymal transition. The SpaceOAR hydrogel system separates the prostate and rectum to reduce rectal irradiation during prostate radiotherapy. However, it could induce rectal toxicity. A 75-year-old man with localized prostate cancer underwent external beam radiot