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Among them, miR-292-5p, miR-155-3p, miR-1193-3p, miR-411-3p, miR-370-3p, and miR-409a-5p were discovered to be likewise modified in rat lung and transforming growth element (TGF)-β1-induced cultured fibroblasts. Using miRNA imitates and inhibitors, we found that miR-1193-3p, miR-411-3p, and miR-370-3p exhibited powerful anti-fibrotic effects, while miR-292-5p demonstrated pro-fibrotic effects in TGF-β1-stimulated lung fibroblasts. Additionally,