https://www.selleckchem.com/pe....ptide/pki-14-22-amid
OBJECTIVES The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that cathelicidin is differentially expressed in various tissues in sepsis. However, its role in sepsis-induced intestinal barrier dysfunction has not been investigated. DESIGN To examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-(Cnlp+/+) and
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