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Furthermore, IH increased left ventricular myocardium expression of the B2 bradykinin receptor, while reducing mRNA levels of B1 receptor. These results suggest that in IH, an unexpected response of the VEGF and KKS systems could explain the reduced capillary density and impaired angiogenesis in the hypoxic heart, with potential implications in hypertrophic heart malfunction.Functional interaction between the selective water channel AQP4 and several ion channels, such as TRPV4, NKCC1, and Na+ /K+ -ATPase, closely participate to regulate