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Tendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes. This review summarizes epigenetic mechanisms identified in ageing healthy tendon. We searched multiple databases to produce a systematic review on the role of epigenetic mechanisms in tendon ageing. Epigenetic mechanisms are important in predisposing age