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The transcripts levels of genes associated with apoptosis confirmed the anti-apoptotic effect of the biomaterials. Increased metabolic activity of MC3T3-E1 in cultures with biomaterials functionalized with Bi3+ ions has been observed. Moreover, the determined profile of osteogenic markers indicates that the obtained matrices, that is, Eu3+nSi-HAp functionalized with Bi3+ ions, exert pro-osteogenic properties. The biological features of Eu3+nSi-HAp modified with Bi3+ ions are highly desired in terms of functional tissue restoration and f
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