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significant role in health system all over the world for both humans and animals. "Mutong" ( in Chinese, and generally known as Akebiae Caulis), which refers to a group of herbal medicines with different biological origins along history, has been used in traditional Chinese medicine for over 2000 years; it is still being frequently used in medicine. In recent decades, Akebiae Caulis has been reported to exhibit apparent toxicity. To clarify the plant species used as Akebiae Caulis and its synonyms, and to summarize their phytochemistry,