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Therefore, mw formed the base of the calibrated GUTS bioavailability model (GUTS-BLM), which predicted 30-d x% lethal concentration (LCx) values within a 2-fold error. The GUTS-BLM was combined with an IBM, inSTREAM-Gen, into a GUTS-BLM-IBM. Assuming that juvenile survival was the only effect of Cu and Zn exposure, population-level effect concentrations were predicted to be 1.3 to 6.2 times higher than 30-d laboratory LCx values, with the larger differences being associated with higher interindividual variation of metal sensitivity. The

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