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The GWAS identified three novel MBC susceptibility loci that attained genome-wide significance (P 5 x 10-08). Genetic correlation analysis revealed a strong shared genetic basis with estrogen-receptor (ER) positive FBC. Males in the top quintile of genetic risk had a four-fold increased risk of breast cancer relative to those in the bottom quintile (odds ratio = 3.86, 95% confidence interval = 3.07 to 4.87, P = 2.08 x 10-3. These findings advance our understanding of the genetic basis of MBC, providing support for an overlapping
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