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diction by the Framingham risk score, with a model likelihood-ratio statistic increase from 10.50 to 20.40 ( =0.002). The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in atherogenesis, was inversely associated with incident cardiovascular events in a general population cohort, independent of HDL cholesterol and HDL cholesterol efflux capacity. Adding HDL anti-inflammatory capacity to the Framingham risk score improves risk prediction. The HDL anti-inflammatory capacity, reflecting vascular protection against key steps in