https://www.selleckchem.com/pr....oducts/trc051384.htm
We found that the AMPK/aPKCζ/CREB pathway was essential for metformin-induced GDNF upregulation and TH activation. Thus, this study reveals the TH-activating property of metformin in the brain via induction of neurotrophic factors along with the signaling mechanism. These results potentiate the candidacy of metformin not only as a neuroprotective agent, but also as restorative therapy for the treatment of PD.When coined, the term "antisense" included oligonucleotides of any structure, with any chemical modification and designed to wor
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