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Treatment For ADHD The most effective treatment options for add are medications and psychosocial therapy (psychotherapy). The medications include stimulants like methylphenidate, amphetamine and atomoxetine. They also include non-stimulants, such as clonidine and Guanfacine. Patients with active issues with addiction are not advised to take stimulant medication. However, those in stable remission might consider them. Combination therapy using antidepressants especially SSR