https://www.selleckchem.com/pr....oducts/fingolimod.ht
Presenting symptoms were headache, disequilibrium, ophthalmoplegia, and panic attack. Eleven tumors showed H3K27M mutation and were diagnosed as diffuse midline gliomas. BRAFV600E, ATRX mutations, PTEN loss, and EGFR amplifications were other molecular alterations detected within tumor samples. Patients with H3K27M mutant tumors had a shorter life span. Five patients were enrolled in an ONC201 trial. Conclusion Although most midline gliomas are not amenable to gross total excision, obtaining tissue samples is mandatory for determinin
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