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To evaluate the association of optic disc deformation with open-angle glaucoma (OAG)-progression risk. Meta-analysis and meta-regression analysis. Reports on the association of optic disc tilt and/or torsion with OAG progression published to June 2020 were identified in the PubMed, EMBASE and Cochrane databases. Tilt ratio was measured as the longest-to-shortest diameter ratio of the optic disc. The angle (in degrees) between the vertical meridian and the disc's long axis was defined as the torsional angle. We utilized random-effects models to combine the p