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Adult ADHD and Comorbid Disorders Many people with ADHD suffer from comorbid disorders, like major depression (Kessler and colleagues, 2006). Many patients do not respond to medication for depression and may be able to benefit from psychotherapy. Medications that most effectively improve core symptoms of ADHD seem to boost and regulate levels of certain neurotransmitters, which are brain chemicals. Stimulants such as methylphenidate and amphetamine are frequently prescribed. Medicines Adults can